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A blood-based prognostic biomarker in IBD 1MB

Authors: D. Biasci, J. C. Lee, N. M. Noor, D. R. Pombal, M. Hou, N. Lewis, T. Ahmad, A. Hart, M. Parkes, E. F. McKinney, P. A. Lyons and K. G. C. Smith

Journal: Gut

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PRedicting Outcomes For Crohn’s dIsease using a moLecular biomarkEr (PROFILE): protocol for a multicentre, randomised, biomarker-stratified trial 0.54MB

Authors: M. Parkes, N. M. Noor, F. Dowling, H. Leung, S. Bond, L. Whitehead, S. Upponi, P. Kinnon, A. P. Sandham, P. A. Lyons, E. F. McKinney, K. G. C. Smith and J. C. Lee

Journal: BMJ Open

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From Big Data to Precision Medicine 2MB

Authors: T. Hulsen, S. S. Jamuar, A. R. Moody, J. H. Karnes, O. Varga, S. Hedensted, R. Spreafico, D. A. Hafler and E. F. McKinney

Journal: Frontiers in Medicine

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Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease 0.00 KB

Authors: J. C. Lee, D. Biasci, R. Roberts, R. B. Gearry, J. C. Mansfield, T. Ahmad, N. J. Prescott, J. Satsangi, D. C. Wilson, L. Jostins, C. A. Anderson, UK IBD Genetics Consortium; J. A. Traherne, P. A. Lyons, M. Parkes and K. G. C. Smith

Journal: Nature Genetics

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T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases 0.00 KB

Authors: E. F. McKinney and K. G. C. Smith

Journal: Immunology & Cell Biology

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T cell exhaustion and immune-mediated disease - the potential for therapeutic exhaustion 0.00 KB

Authors: E. F. McKinney and K. G. C. Smith

Journal: Current Opinion in Immunology

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T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection 0.00 KB

Authors: E. F. McKinney, J. C. Lee, D. R. W. Jayne, P. A. Lyons and K. G. C. Smith

Journal: Nature

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T-cell exhaustion limits immune reactivity and is associated with good prognosis in autoimmune disease 0.42MB

Authors: E. F. Carney

Journal: Nature Reviews Rheumatology

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Benefits of exhaustion 0.4MB

Authors: O. Leavy

Journal: Nature Reviews Immunology

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Signatures of CD4 T-cell help and CD8 exhaustion predict clinical outcome in autoimmunity, infection, and vaccination 41.5KB

Authors: E. F. McKinney, J. C. Lee, P. A. Lyons, T. F. Rayner, E. J. Carr, A. Hatton, D. R. W. Jayne, L. C. Willcocks, A. N. Chaudhry and K. G. C Smith

Journal: The Lancet

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