T-cells and immune-mediated inflammatory disease
PredictImmune’s core technology utilises biomarkers that identify a natural immunological state known as exhaustion. Exhaustion is a state of cellular dysfunction which reduces the ability of activated immune cells called T-cells to fight against chronic infection.
In exhaustion, prolonged killer T-cell activation results in a downregulation of their ability to kill target cells, to produce inflammatory signals and to divide and produce new T-cells.
T-cells also play an important role in “self-reactive” responses, causing inflammation and damage to healthy tissue central to immune-mediated inflammatory diseases. In this context, T-cell exhaustion can be helpful and has been linked to better long-term outcomes in immune diseases such as inflammatory bowel disease.